For Basel Institute for Immunology 40th anniversary celebration, 9 – 10th June 2011
Even though my stay at the Basel Institute for Immunology (BII) was rather brief, it was highly illuminating and had a major impact on my future career as an immunologist. I was most impressed by the spirit of openness and collegiality of the institute, where I was immediately integrated into the BII's research community. The BII was a leader for many immunologists mostly for two reasons: First, its goal of highest scientific originality, precision, and quality and second, its spirit, which immediately convinced its members to whole-heartedly follow suit. I know that this is an over-simplification but the enormous output of leaders in immunology clearly argues for its success. They say performance depends on attitude and judging from the BII's track record, its overwhelmingly positive attitude is obvious, and the contagiousness of its attitude has succeeded in imprinting a spirit of quality and openness in research to the many students, post-docs and researches who have walked through its doors. I am proud to have been there – to have learned about the art and tools of immunological research – at the most vibrant center of its kind.
Stefan H.E. Kaufmann
Max Planck Institute for Infection Biology, Berlin
President, International Union of Immunological Society
6th April, 2011
Index
Who is Who of the BII-Alumni Coverpage
Introduction
Greetings from President of IUIS
Scientists (ABC Family Name Order) page
Berek Claudia 11
Bogen Bjarne 12
Chen Una 13
Dembic Zlatko 14
Fathman Garry 15
Flajnik Martin 16
Gerson Donald 17
Gisler Roland 18
Günthert Ursula 19
Hamilton John 20
Hansen John 21
Hengartner Hans 22
Heusser Christoph 23
Jacobs Heinz 24
Julius Michael 25
Kapasi Zoher 26
Karasuyama Hejime 27
Kaufman Jim 28
Kaufmann Stefan 29
Kettman Jack 30
Kincade Paul 31
Kisielow Pawel 32
Lamers Marinus 33
Lassila Olli 34
Leanderson Tomas 35
Mackay Charles 36
Marcu Kenneth 37
Mayr Wolfgang 38
Ohnishi Kazuo 39
Pink Richard 40
Ramseier Hansruedy 41
Riesen Walter 42
Sakaguchi Nobuo 43
Salio Mariolina 44
Shulman Marc 45
Sidman Charles 46
Tyndall Alan 47
von Borster Jack 48
Wallny Hans-Joachim 49
Students page
Borggrefe Tilman 53
Ghia Paolo 54
Jäck Hans-Martin 55
Padovan Elisabetta 56
Schmitz Nicole 57
Ziegler Andreas 58
Staff
Anquez Viviane 61
Dangy Jean-Pierre 62
Lang Rosmarie 63
Marcuz Anne 64
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Contributed by
1. Hansruedy Ramseier (received June 28, 2011)
and more
(Received, June 28, 2011)
June 11, 2001
Prof. Dr. F. Melchers
Muttenzerstrasse 29
D-79639 Grenzach
Dear Fritz!
Thank you for your letter of April 6, 2001. In response to your request, I shall be pleased to summarize the three topics you asked to be dealt with.
1) What was I, and what did I do in science, before I joined the institute?
When I returned with my family from the US to Switzerland in 1965, (a move not done voluntarily, because Bill Billingham then at the University of Pennsylvania, Philadelphia offered me an assistant professorship, an offer which I could not take advantage of because of lack of an immigration visa), I was offered by Lean Lindenmann the position as a chief assistant (Oberassistent) at the Institute of Medical Microbiology, Division of Experimental Microbiology, University of Zürich. There I continued my research in transplantation immunology. In particular I followed up the ideas put down in papers with Billingham and later Streilein (Ann. N.Y. Acad. Sci.,120: 379,1964; JEM,123: 629,1966; Lancet, 1: 622,1965). These showed that mixtures of lymphoid cells from genetically different inbred strains of mice, rats and hamsters, when injected into the skins of lethally irradiated hamsters produced skin reactions of delayed type hypersensitivity character. By changing to in vitro technology, it turned out that such mixtures of immune-competent lymphoid cells when cultivated secreted into the medium some factor which, when concentrated by lyophilisation, then reconstituted 10x and injected i.d. into irradiated (but as shown later also normal) hamsters attracted polymorphonuclear (PMN) cells. To quantitate the degree of PMN accumulations, skin reactions were excised, cut into small fragments, which were trypsinized, and PMNs thus released were counted. The numbers of PMNs in skin reactions followed the degree of histoin-compatibility and immune-competence (Science, 157: 554, 1967). This factor was later called PAR for “Product of Antigenic Recognition”. As these studies elaborated it became clear that PAR must be induced by recognition of foreign transplantation antigens by immune-competent T lymphocytes. Efforts, therefore, concentrated on the (then largely mysterious) T cell receptor. In collaboration with Lindenmann, adult F1 hybrid animals from the three species mentioned were immunized with lymphoid cells from one of the parental strains. In the sera of all species of so treated animals an activity could be found which specifically inhibited recognition of transplantation antigens by cells of the immunizing parent of the other parent present on F1 hybrid cells. These data showed that F1 hybrids could form antibodies against those receptors, which they lacked for genetic reasons (Path. Microbiol., 34: 379, 1969). I think these data gave perhaps the first indication on the existence of the T cell receptor for transplantation antigens, for receptors (then called Recognition Structures, RS) could be inhibited specifically. They furthermore had to do with idiotypic problems and as a result of some correspondence with Niels Jerne, he invited me to join the Basel Institute for Immunology. This I did from spring 1971 to spring 1973. In April 1970 I was promoted to assistant professor of the Medical Faculty, University of Zürich.
2) What did I do, and achieve, while I was at the institute?
Even before joining the institute, I tried hard to replace the cumbersome PAR test by some more accepted, conventional test system, but I failed (as I did also many times later). To do this I had plenty of time, because all lyophilizers at the institute were not capable of drying the culture supernatants properly, but thawed the material and thus inactivated it. After about six months I went to see you, Fritz, and declared that if I do not get the same lyophilizer as I had in Zürich, and which worked very well, I would return to Zürich. I then got it. This, by the way, turned out to be the main problem of the fact that, with the exception of Hans Binz (e.g. J. Immunol., 111:1108, 1973), nobody could reproduce the PAR test. Although I instructed a number of people on the problem of lyophylization, nobody seemed to take the problem of thawing and inactivation seriously. At the institute, the finding made in Zürich that an allo-antiserum-A anti-B carried the same “recognition sites” as do immune-competent-A T-cells, was followed up. Antibodies raised against such allo-antibodies blocked the T-ceIl receptor just as specifically as did the cell-induced antibodies described above. Thus, a possible similarity between recognition structures on immune-competent T-cells and the antigen-binding sites of allo-antibodies aimed at the same target could be shown (JEM, 134:1083, 1971, Eur. J.Immunol., 2: 109, 1971). In addition, the “education” of T- and B- (thymus) cells to recognize transplantation antigens was studied and revealed activity by their capacity to form aIlo-antibodies and induce formation of anti-RS antibodies (Cell. Imm., 8:177, 1973). Also, studies on the nature of PAR showed that it is formed whenever T- but not B-cells were confronted with allo-antigens (Nature, 246:351, 1973). Using congenic strains of mice, the fine structure of T-cell receptors for H-2 antigenic specificities could be demonstrated (Eur. J. Immunol., 3: 164, 1973). Furthermore, it was found that mice could be immunized against abolition of tolerance by heavy doses of otherwise effective transplantation tolerance-breaking cells due to induced formation of anti-RS antibodies in “immunized” tolerant mice (Eur. J. Immunol., 3:156, 1973).
3) What did I become after left the institute, and what impact did my work at the institute have on my career afterwards?
My stay at the institute and the “call” by Niels Jerne to become a permanent member, certainly helped that I was promoted to the position of an extraordinary professor in 1975. Before that, alas, my salary dropped by about 20 percent! Unfortunately, I had very little collaboration during my stay at the institute, most likely because of my unconventional test system and a general lack of urgent interest in transplantation immunology. Only J. F. A. P. Miller showed interest in acollaboration, but one test not giving the expected result, stopped it. Later on, Hans Binz and Hans Wigzell succeeded in confirming many aspects of results obtained with the PAR assays, using different immunization procedures allowing conventional tests.
Well, Fritz, I hope this is what you expected in your letter. As you wished, I shall also put this down this in handwriting, but in case you have difficulties in deciphering my hieroglyphs, this should help as the "Rosetta stone".
I hope sincerely that your “state of transition” will soon end and will find a satisfactory solution.
Sincerely yours,
Hansruedy Ramseier
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